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KoCoImpf study for COVID-19 vaccinated people

The aim of the KoCoImpf study was to better understand the short-, medium-, and long-term serological immune response in individuals vaccinated against SARS-CoV-2. To this end, over 6,000 participants were enrolled in the study—primarily healthcare professionals—each of whom had received at least one COVID-19 vaccination.

Between June 2021 and July 2022, capillary blood samples were collected from the fingertip in two rounds to detect SARS-CoV-2 antibodies. These antibodies provide insights into both asymptomatic and symptomatic infections, as well as vaccination behavior. In addition, questionnaire data were collected.

The analysis of the first data collection round, conducted between June 2021 and December 2021, focused on identifying factors influencing the immune response following SARS-CoV-2 infection or vaccination, as well as risk factors for infection. The second data collection, conducted between May 2022 and July 2022, aimed to better understand the impact of the Omicron variant. This included examining differences in infection risk factors, breakthrough infections, and reinfections.


Many thanks to all participants!

The study results have been described in detail in two publications:

Study results

Understanding the Omicron Variant Impact in Healthcare Workers: Insights from the Prospective COVID-19 Post-Immunization Serological Cohort in Munich (KoCo-Impf) on Risk Factors for Breakthrough and Reinfections.
Janke C, Rubio-Acero R, Weigert M, Reinkemeyer C, Khazaei Y, Kleinlein L, Le Gleut R, Radon K, Hannes M, Picasso F, et al.
Viruses. 2024; 16(10):1556.

The Prospective COVID-19 Post-Immunization Serological Cohort in Munich (KoCo-Impf): Risk Factors and Determinants of Immune Response in Healthcare Workers.
Reinkemeyer C, Khazaei Y, Weigert M, Hannes M, Le Gleut R, Plank M, Winter S, Noreña I, Meier T, Xu L, et al.
Viruses. 2023; 15(7):1574.

Contact for participants

Please note that the telephone study hotline for the KoCo vaccination study is no longer active.

You can still reach us by e-mail:
KoCo19@med.uni-muenchen.de

Further information about the study

Study cooperations

The project was also funded by the pan-European consortium ORCHESTRA. The ORCHESTRA project has received funding from the European Union's Horizon 2020 research and innovation program under grant agreement No 101016167. This publication reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.