Research Group: Transplantation and Transplant Oncology
Welcome to the homepage of the Research Group for Transplantation and Transplant Oncology, where innovation and collaboration drive advancements in organ transplantation and oncology. Our group comprises two primary focus areas:
1. LMU Transplant Engineering Lab
2. Liver Transplant Oncology Study Group
LMU Transplant Engineering Lab
Our Mission
The LMU Transplant Engineering Lab is committed to transforming the field of organ transplantation by improving donor organ viability and functionality while reducing reliance on systemic immunosuppression. Our work seeks to redefine transplantation science through cutting-edge research and engineering.
Core Innovation: The Immunedit Platform
A flagship project of the lab, the Immunedit Platform focuses on modifying donor organ immune profiles via gene regulatory and gene-editing methodologies during normothermic, oxygenated machine perfusion. This innovative approach aims to minimize rejection risk and improve long-term transplant outcomes.
Collaborative Opportunities
We welcome interdisciplinary partnerships with researchers, clinicians, and institutions striving to advance transplantation medicine. Our lab is eager to share insights and collaborate on transformative projects.
For further inquiries or to explore our recent publications, please contact Dionysios.Koliogiannis@med.uni-muenchen.de
Acknowledgment of Funding
Our research is generously supported by the DFG and Else Kröner Fresenius Foundation whose contributions are essential to our mission and success.
Liver Transplant Oncology Study Group
Our Mission
The Liver Transplant Oncology Study Group focuses on the intersection of liver transplantation and the treatment of liver cancers, particularly hepatocellular carcinoma (HCC), cholangiocarcinoma and colorectal liver metastases. We aim to push the boundaries of understanding, innovation, and clinical outcomes in liver transplant oncology through cutting-edge research and collaboration.
Key Objectives
• Advance interdisciplinary research on liver transplantation for oncology indications.
• Refine selection criteria by integrating tumor biology, biomarkers, and genomic insights.
• Optimize peri-transplant cancer therapies such as bridging, downstaging, cell-based- and immunotherapy.
• Improve strategies to mitigate post-transplant cancer recurrence while balancing immunosuppression.
• Expand global access to transplantation for patients with oncological indications.
Clinical Studies
Initiated Studies
• RAPID-MUC: Partial liver segment 2/3 transplantation with delayed total hepatectomy as a treatment for selected patients with liver metastases from colorectal carcinoma. (PI: Markus Guba; Recruiting)
• TRANSMIT: Utilizing discarded livers from donors with a history of cancer for patients lacking access to standard allocation. A compassionate use exploratory study. (PI: Markus Guba; Recruiting)
• Registerstudie zur Lebertransplantation bei nicht resektablen kolorektalen Lebermetastasen [German Transplant Oncology Trial] (PI: Nathanael Raschzok, Markus Guba, Andreas Pascher; In preparation)
Collaborative Studies
• PRODUCT: [Add description if available].
• LEOPARD: Liver Electronic Offering Platform with Artificial Intelligence-based Devices. (PI: Christophe Duvoux; In preparation)
Collaborative Opportunities
We collaborate with transplant centers, oncologists, and healthcare institutions worldwide, facilitating multicenter studies and data-sharing initiatives. Our group is dedicated to publishing high-impact research and developing evidence-based clinical guidelines.
For collaboration proposals or to explore our ongoing work, please contact Markus.Guba@med.uni-muenchen.de
Acknowledgment of Funding
Our research initiatives are supported by various funding agencies committed to advancing liver transplant oncology.
By uniting expertise in transplant engineering and oncology, our research group strives to shape the future of transplant medicine, improve patient outcomes, and expand access to life-saving therapies. We look forward to connecting with like-minded researchers and clinicians.
Team
Prof. Dr. med. Markus Guba Markus.Guba@med.uni-muenchen.de
Dr. med. Dionysios Koliogiannis Dionysios.Koliogiannis@med.uni-muenchen.de
PD Dr. med. Nikolaus Börner Nikolaus.Boerner@med.uni-muenchen.de
Dr. med. Dominik Koch Dominik.Koch@med.uni-muenchen.de
Dr. med. Malte Schirren Malte.Schirren@med.uni-muenchen.de
Dr. med. Severin Jacobi Severin.Jacobi@med.uni-muenchen.de
