Spokesperson
Prof. Dr. med. vet. Eckhard Wolf
LMU Munich Institut of Molecular Animal Breeding and Biotechnology Gene Center and Department of Veterinary Science
Feodor-Lynen-Str. 25
81377 München
+49 (0) 89 2180 76800
81377 München
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Publications (selected)
2021
- Viable pigs after simultaneous inactivation of porcine MHC class I and three xenoreactive antigen genes GGTA1, CMAH and B4GALNT2
- Growth hormone receptor knockout to reduce the size of donor pigs for preclinical xenotransplantation studies
- Transgenic pigs expressing near infrared fluorescent protein—A novel tool for noninvasive imaging of islet xenotransplants
- Pathways to Clinical Cardiac Xenotransplantation
2020
2019
2018
- Multiple genetically modified GTKO/hCD46/HLA-E/hβ2-mg porcine hearts are protected from complement activation and natural killer cell infiltration during ex vivo perfusion with human blood
- Early weaning completely eliminates porcine cytomegalovirus from a newly established pig donor facility for xenotransplantation
- Porcine endogenous retroviruses: Quantification of the copy number in cell lines, pig breeds, and organs
- Distribution of Porcine Cytomegalovirus in Infected Donor Pigs and in Baboon Recipients of Pig Heart Transplantation
- Third WHO Global Consultation on Regulatory Requirements for Xenotransplantation Clinical Trials, Changsha, Hunan, China December 12-14, 2018: "The 2018 Changsha Communiqué" The 10-Year Anniversary of The International Consultation on Xenotransplantation
- Growth hormone receptor-deficient pigs resemble the pathophysiology of human Laron syndrome and reveal altered activation of signaling cascades in the liver
- Will Genetic Engineering Carry Xenotransplantation of Pig Islets to the Clinic?
- Recent progress in porcine islet isolation, culture and engraftment strategies for xenotransplantation
- Use of Xenogeneic Cells. Cell Engineering and Regeneration
- Animal models of obesity and diabetes mellitus
- Targeting αGal epitopes for multi-species embryo immunosurgery
- Consistent success in life-supporting porcine cardiac xenotransplantation
- Release of pig leukocytes and reduced human NK cell recruitment during ex vivo perfusion of HLA-E/human CD46 double-transgenic pig limbs with human blood
- Wolf, E. et al., Genetisch modifizierte Schweine als Zell, Gewebe- und Organquelle. Tierische Organe in menschlichen Körpern (2018), pp. 65–86.
2017
- LEA29Y expression in transgenic neonatal porcine islet-like cluster promotes long-lasting xenograft survival in humanized mice without immunosuppressive therapy
- Vessel Network Architecture of Adult Human Islets Promotes Distinct Cell-Cell Interactions In Situ and Is Altered After Transplantation
- Diabetes Mellitus-Induced Microvascular Destabilization in the Myocardium
- INS-eGFP transgenic pigs: a novel reporter system for studying maturation, growth and vascularisation of neonatal islet-like cell clusters
2016
- Progress in Clinical Encapsulated Islet Xenotransplantation
- Ubiquitous LEA29Y Expression Blocks T Cell Co-Stimulation but Permits Sexual Reproduction in Genetically Modified Pigs
- Efficient production of multi-modified pigs for xenotransplantation by 'combineering', gene stacking and gene editing
- Developmental endothelial locus-1 modulates platelet-monocyte interactions and instant blood-mediated inflammatory reaction in islet transplantation
- Inhibition of complement component C5 prevents clotting in an ex vivo model of xenogeneic activation of coagulation
2015
- Pigs pave a way to de novo formation of functional human kidneys. Proceedings of the National Academy of Sciences of the United States of America 112, 12905-12906.
- Xenotransplantation of porcine islet cells as a potential option for the treatment of type 1 diabetes in the future
- Engraftment and reversal of diabetes after intramuscular transplantation of neonatal porcine islet-like clusters
2014 - 2009
- Fine mapping of genome activation in bovine embryos by RNA sequencing. Proceedings of the National Academy of Sciences of the United States of America 111, 4139-4144
- Homologous recombination contributes to the repair of zinc-finger-nuclease induced double strand breaks in pig primary cells and facilitates recombination with exogenous DNA. Journal of biotechnology 177, 74-81.
- Permanent neonatal diabetes in INS(C94Y) transgenic pigs
- Protein O-mannosylation is crucial for E-cadherin-mediated cell adhesion. Proceedings of the National Academy of Sciences of the United States of America 110, 21024-21029.
- Dystrophin-deficient pigs provide new insights into the hierarchy of physiological derangements of dystrophic muscle. Human molecular genetics 22, 4368-4382.
- Changing metabolic signatures of amino acids and lipids during the prediabetic period in a pig model with impaired incretin function and reduced beta-cell mass.
- Xenografted islet cell clusters from INSLEA29Y transgenic pigs rescue diabetes and prevent immune rejection in humanized mice. Diabetes 61, 1527-1532.
- Sequential targeting of CFTR by BAC vectors generates a novel pig model of cystic fibrosis. Journal of molecular medicine 90, 597-608.
- Sequential targeting of CFTR by BAC vectors generates a novel pig model of cystic fibrosis
- https://faseb.onlinelibrary.wiley.com/doi/epdf/10.1096/fj.11-185041
- Glucose Intolerance and Reduced Proliferation of Pancreatic β-Cells in Transgenic Pigs With Impaired Glucose-Dependent Insulinotropic Polypeptide Function
- The endometrium responds differently to cloned versus fertilized embryos
- HLA-E/human beta2-microglobulin transgenic pigs: protection against xenogeneic human anti-pig natural killer cell cytotoxicity
