Institute of Musculoskeletal Medicine (IMM)
  1. Startseite LMU Klinikum
  2. Institute of Musculoskeletal Medicine (IMM)
  3. Publications

Publications

  • Single-cell Transcriptomic Analysis Identifies Senescent Osteocytes that Trigger Bone Destruction in Breast Cancer Metastasis. Kaur J, Adhikari M, Sabol HM, Anloague A, Khan S, Kurihara N, Diaz-delCastillo M, Andreasen CM, Barnes CL, Stambough JB, Palmieri M, Reyes-Castro O, Zarrer J, Taipaleenmäki H, Ambrogini E, Almeida M, O'Brien C, Nookaew I, Delgado-Calle J. Cancer Res. 2024 Sep 23. doi: 10.1158/0008-5472.CAN-24-0857. PMID: 39312185
  • Recommendations for the optimal use of bone forming agents in osteoporosis. Veronese N, Briot K, Guañabens N, Albergaria BH, Alokail M, Al-Daghri N, Bemden AB, Bruyère O, Burlet N, Cooper C, Curtis EM, Ebeling PR, Halbout P, Hesse E, Hiligsmann M, Camargos BM, Harvey NC, Perez AD, Radermecker RP, Reginster JY, Rizzoli R, Siggelkow H, Cortet B, Brandi ML. Aging Clin Exp Res. 2024 Aug 9;36(1):167. doi: 10.1007/s40520-024-02826-3. PMID: 39120740
  • Tgif1-deficiency impairs cytoskeletal architecture in osteoblasts by activating PAK3 signaling. Bolamperti S, Saito H, Heerdmann S, Hesse E, Taipaleenmäki H. Elife. 2024 Apr 25;13:RP94265. doi: 10.7554/eLife.94265. PMID: 38661167
  • The osteoblast in regulation of tumor cell dormancy and bone metastasis. Zarrer J, Taipaleenmäki H. J Bone Oncol. 2024 Mar 21;45:100597. doi: 10.1016/j.jbo.2024.100597. eCollection 2024 Apr. PMID: 38550395

  • Fibrous Dysplasia of the Jaw: Advances in Imaging and Treatment. Obermeier KT, Hartung JT, Hildebrandt T, Dewenter I, Smolka W, Hesse E, Fegg F, Otto S, Malenova Y, Abdullah A. J Clin Med. 2023 Jun 17;12(12):4100. doi: 10.3390/jcm12124100. PMID 37373793
  • Redefining stem cells through their use in musculoskeletal tissue preservation, regeneration, and cancer metastases to bone. Drissi H, Taipaleenmäki H, Jorgensen C. Bone Rep. 2023 Apr 6;19:101678. doi: 10.1016/j.bonr.2023.101678. PMID: 38163014
  • Secreted microRNAs in bone metastasis. Taipaleenmäki H. J Bone Miner Metab. 2023 May;41(3):358-364. doi: 10.1007/s00774-023-01424-z. Epub 2023 Apr 8. PMID: 37031329

  • Regulation of bone homeostasis by MERTK and TYRO3. Engelmann J, Zarrer J, Gensch V, Riecken K, Berenbrok N, Luu TV, Beitzen-Heineke A, Vargas-Delgado ME, Pantel K, Bokemeyer C, Bhamidipati S, Darwish IS, Masuda E, Burstyn-Cohen T, Alberto EJ, Ghosh S, Rothlin C, Hesse E, Taipaleenmäki H, Ben-Batalla I, Loges S. Nat Commun. 2022 Dec 12;13(1):7689. doi: 10.1038/s41467-022-33938-x. PMID: 36509738
  • SFRP2 Overexpression Induces an Osteoblast-like Phenotype in Prostate Cancer Cells. Akova Ölken E, Aszodi A, Taipaleenmäki H, Saito H, Schönitzer V, Chaloupka M, Apfelbeck M, Böcker W, Saller MM. Cells. 2022 Dec 16;11(24):4081. doi: 10.3390/cells11244081. PMID: 36552843
  • R-spondin 3 deletion induces Erk phosphorylation to enhance Wnt signaling and promote bone formation in the appendicular skeleton. Nagano K, Yamana K, Saito H, Kiviranta R, Pedroni AC, Raval D, Niehrs C, Gori F, Baron R. Elife. 2022 Nov 2;11:e84171. doi: 10.7554/eLife.84171. PMID: 36321691
  • Antagonizing microRNA-19a/b augments PTH anabolic action and restores bonemass in osteoporosis in mice. Taipaleenmäki H, Saito H, Schröder S, Maeda M, Mettler R, Ring M, Rollmann E, Gasser A, Haasper C, Gehrke T, Weiss A, Grimm SK, Hesse E. EMBO Mol Med. 2022 Oct 4:e13617. doi: 10.15252/emmm.202013617. PMID: 36193848
  • Muscle and Bone Defects in Metastatic Disease. Pauk M, Saito H, Hesse E, Taipaleenmäki H. Curr Osteoporos Rep. 2022 Oct;20(5):273-289. doi: 10.1007/s11914-022-00741-y. PMID: 35994202
  • Single-Cell RNA-Sequencing Leading to Breakthroughs in Musculoskeletal Research. Ono N, Taipaleenmäki H, Veis DJ. JBMR Plus. 2022 Jun 6;6(7):e10652. doi: 10.1002/jbm4.10652. PMID: 35866151
  • MicroRNAs: Emerging Regulators of Metastatic Bone Disease in Breast Cancer. Haider MT, Smit DJ, Taipaleenmäki H. Cancers (Basel). 2022 Jan 30;14(3):729. doi: 10.3390/cancers14030729. PMID: 35158995
  • Exosomal miRNAs from Prostate Cancer Impair Osteoblast Function in Mice. Furesi G, de Jesus Domingues AM, Alexopoulou D, Dahl A, Hackl M, Schmidt JR, Kalkhof S, Kurth T, Taipaleenmäki H, Conrad S, Hofbauer C, Rauner M, Hofbauer LC. Int J Mol Sci. 2022 Jan 24;23(3):1285. doi: 10.3390/ijms23031285. PMID: 35163219

  • Parathyroid hormone signaling in mature osteoblasts/osteocytes protects mice from age-related bone loss. Uda Y, Saini V, Petty CA, Alshehri M, Shi C, Spatz JM, Santos R, Newell CM, Huang TY, Kochen A, Kim JW, Constantinou CK, Saito H, Held KD, Hesse E, Pajevic PD. Aging (Albany NY). 2021 Dec 30;13(24):25607-25642. doi: 10.18632/aging.203808. PMID: 34968192
  • [Individual aspects in elderly patients with fragility fractures]. Fleischhacker E, Gleich J, Hesse E, Bücking B, Liener UC, Neuerburg C. Radiologe. 2021 Dec;61(12):1107-1114. doi: 10.1007/s00117-021-00928-x. PMID: 34767032
  • Romosozumab Followed by Antiresorptive Treatment Increases the Probability of Achieving Bone Mineral Density Treatment Goals. Cosman F, Libanati C, Deignan C, Yu Z, Wang Z, Ferrari S, Beck Jensen JE, Peris P, Bertoldo F, Lespessailles E, Hesse E, Cummings SR. JBMR Plus. 2021 Oct 6;5(11):e10546. doi: 10.1002/jbm4.10546. PMID: 34761149
  • Non-coding RNAs in bone remodelling and bone metastasis: Mechanisms of action and translational relevance. Puppo M, Taipaleenmäki H, Hesse E, Clézardin P. Br J Pharmacol. 2021 May;178(9):1936-1954. doi: 10.1111/bph.14836. PMID: 31423566
  • Interleukins as Mediators of the Tumor Cell-Bone Cell Crosstalk during the Initiation of Breast Cancer Bone Metastasis. Haider MT, Ridlmaier N, Smit DJ, Taipaleenmäki H. Int J Mol Sci. 2021 Mar 12;22(6):2898. doi: 10.3390/ijms22062898. PMID: 33809315
  • Multiscale molecular profiling of pathological bone resolves sexually dimorphic control of extracellular matrix composition. Sharma A, Goring A, Johnson PB, Emery RJH, Hesse E, Boyde A, Olsen BR, Pitsillides AA, Oreffo ROC, Mahajan S, Clarkin CE. Dis Model Mech. 2021 Mar 1;14(3):dmm048116. doi: 10.1242/dmm.048116. PMID: 33563616
  • Osteoporosis Treatment with Anti-Sclerostin Antibodies-Mechanisms of Action and Clinical Application. Rauner M, Taipaleenmäki H, Tsourdi E, Winter EM. J Clin Med. 2021 Feb 16;10(4):787. doi: 10.3390/jcm10040787. PMID: 33669283
  • Editorial: RNA-Mediated Processes in Epigenetics; an Integrative View in the Maintenance of Homeostasis. Kaeffer B, Taipaleenmäki H, de Souza SL. Front Genet. 2021 Feb 3;11:629918. doi: 10.3389/fgene.2020.629918. PMID: 33613627

  • Mechanical strain-mediated reduction in RANKL expression is associated with RUNX2 and BRD2. Galea GL, Paradise CR, Meakin LB, Camilleri ET, Taipaleenmaki H, Stein GS, Lanyon LE, Price JS, van Wijnen AJ, Dudakovic A. Gene. 2020 Dec;763S:100027. doi: 10.1016/j.gene.2020.100027. PMID: 34493364
  • Interleukin-9 protects from early podocyte injury and progressive glomerulosclerosis in Adriamycin-induced nephropathy. Xiong T, Attar M, Gnirck AC, Wunderlich M, Becker M, Rickassel C, Puelles VG, Meyer-Schwesinger C, Wiech T, Nies JF, Divivier M, Fuchs T, Schulze Zur Wiesch J, Taipaleenmäki H, Hoxha E, Wirtz S, Huber TB, Panzer U, Turner JE. Kidney Int. 2020 Sep;98(3):615-629. doi: 10.1016/j.kint.2020.04.036. PMID: 32446933
  • T-Score as an Indicator of Fracture Risk During Treatment With Romosozumab or Alendronate in the ARCH Trial. Cosman F, Lewiecki EM, Ebeling PR, Hesse E, Napoli N, Matsumoto T, Crittenden DB, Rojeski M, Yang W, Libanati C, Ferrari S. J Bone Miner Res. 2020 Jul;35(7):1333-1342. doi: 10.1002/jbmr.3996. PMID: 32445228
  • Breast cancer bone metastases are attenuated in a Tgif1-deficient bone microenvironment. Haider MT, Saito H, Zarrer J, Uzhunnumpuram K, Nagarajan S, Kari V, Horn-Glander M, Werner S, Hesse E, Taipaleenmäki H. Breast Cancer Res. 2020 Apr 9;22(1):34. doi: 10.1186/s13058-020-01269-8. PMID: 32272947
  • The Endosteal Niche in Breast Cancer Bone Metastasis. Haider MT, Smit DJ, Taipaleenmäki H. Front Oncol. 2020 Mar 13;10:335. doi: 10.3389/fonc.2020.00335. PMID: 32232008
  • Pathological Crosstalk between Metastatic Breast Cancer Cells and the Bone Microenvironment. Zarrer J, Haider MT, Smit DJ, Taipaleenmäki H. Biomolecules. 2020 Feb 19;10(2):337. doi: 10.3390/biom10020337. PMID: 32092997

  • Regulation of the Bone Vascular Network is Sexually Dimorphic. Goring A, Sharma A, Javaheri B, Smith RC, Kanczler JM, Boyde A, Hesse E, Mahajan S, Olsen BR, Pitsillides AA, Schneider P, Oreffo RO, Clarkin CE. J Bone Miner Res. 2019 Nov;34(11):2117-2132. doi: 10.1002/jbmr.3825. PMID: 31269275
  • [Importance of osteoporosis-related fractures for patients]. Maus U, Böcker W, Schultz K, Maier GS, Weber I, Hesse E. Unfallchirurg. 2019 Oct;122(10):750-754. doi: 10.1007/s00113-019-00708-2. PMID: 31440789
  • [Influence of specific osteoporosis drugs on fracture healing]. Hesse E, Neuerburg C, Kammerlander C, Stumpf U, Stange R, Böcker W. Unfallchirurg. 2019 Jul;122(7):506-511. doi: 10.1007/s00113-019-0669-x. PMID: 31123799
  • [Fracture healing gone astray: Importance of nonsurgical influencing factors]. Hesse E. Unfallchirurg. 2019 Jul;122(7):498-499. doi: 10.1007/s00113-019-0680-2. PMID: 31289911
  • MicroRNAs in Bone Metastasis. Hesse E, Taipaleenmäki H. Curr Osteoporos Rep. 2019 Jun;17(3):122-128. doi: 10.1007/s11914-019-00510-4. PMID: 30905007
  • Sclerostin inhibition alleviates breast cancer-induced bone metastases and muscle weakness. Hesse E, Schröder S, Brandt D, Pamperin J, Saito H, Taipaleenmäki H. JCI Insight. 2019 Apr 9;5(9):e125543. doi: 10.1172/jci.insight.125543. PMID: 30965315
  • TG-interacting factor 1 (Tgif1)-deficiency attenuates bone remodeling and blunts the anabolic response to parathyroid hormone. Saito H, Gasser A, Bolamperti S, Maeda M, Matthies L, Jähn K, Long CL, Schlüter H, Kwiatkowski M, Saini V, Pajevic PD, Bellido T, van Wijnen AJ, Mohammad KS, Guise TA, Taipaleenmäki H, Hesse E. Nat Commun. 2019 Mar 22;10(1):1354. doi: 10.1038/s41467-019-08778-x. PMID: 30902975

  • Determination of bone density in patients with sacral fractures via CT scan. Berger-Groch J, Thiesen DM, Ntalos D, Grossterlinden LG, Hesse E, Fensky F, Hartel MJ. Orthop Traumatol Surg Res. 2018 Nov;104(7):1037-1041. doi: 10.1016/j.otsr.2018.07.022. Epub 2018 Sep 20. PMID: 30243677
  • High-Fat Diet-Induced Obesity Promotes Expansion of Bone Marrow Adipose Tissue and Impairs Skeletal Stem Cell Functions in Mice. Tencerova M, Figeac F, Ditzel N, Taipaleenmäki H, Nielsen TK, Kassem M. J Bone Miner Res. 2018 Jun;33(6):1154-1165. doi: 10.1002/jbmr.3408. PMID: 29444341
  • BET-inhibition by JQ1 promotes proliferation and self-renewal capacity of hematopoietic stem cells. Wroblewski M, Scheller-Wendorff M, Udonta F, Bauer R, Schlichting J, Zhao L, Ben Batalla I, Gensch V, Päsler S, Wu L, Wanior M, Taipaleenmäki H, Bolamperti S, Najafova Z, Pantel K, Bokemeyer C, Qi J, Hesse E, Knapp S, Johnsen S, Loges S. Haematologica. 2018 Jun;103(6):939-948. doi: 10.3324/haematol.2017.181354. PMID: 29567778
  • Targeting the Metastatic Bone Microenvironment by MicroRNAs. Haider MT, Taipaleenmäki H. Front Endocrinol (Lausanne). 2018 Apr 27;9:202. doi: 10.3389/fendo.2018.00202. PMID: 29780354
  • Regulation of Bone Metabolism by microRNAs. Taipaleenmäki H. Curr Osteoporos Rep. 2018 Feb;16(1):1-12. doi: 10.1007/s11914-018-0417-0. PMID: 29335833
  • Inducible podocyte-specific deletion of CTCF drives progressive kidney disease and bone abnormalities. Christov M, Clark AR, Corbin B, Hakroush S, Rhee EP, Saito H, Brooks D, Hesse E, Bouxsein M, Galjart N, Jung JY, Mundel P, Jüppner H, Weins A, Greka A. JCI Insight. 2018 Feb 22;3(4):e95091. doi: 10.1172/jci.insight.95091. PMID: 29467330

  • Increased levels of sodium chloride directly increase osteoclastic differentiation and resorption in mice and men. Wu L, Luthringer BJC, Feyerabend F, Zhang Z, Machens HG, Maeda M, Taipaleenmäki H, Hesse E, Willumeit-Römer R, Schilling AF. Osteoporos Int. 2017 Nov;28(11):3215-3228. doi: 10.1007/s00198-017-4163-4. PMID: 28849275
  • Simultaneous visualisation of calcified bone microstructure and intracortical vasculature using synchrotron X-ray phase contrast-enhanced tomography. Núñez JA, Goring A, Hesse E, Thurner PJ, Schneider P, Clarkin CE. Sci Rep. 2017 Oct 16;7(1):13289. doi: 10.1038/s41598-017-13632-5. PMID: 29038597

  • Antagonizing miR-218-5p attenuates Wnt signaling and reduces metastatic bone disease of triple negative breast cancer cells. Taipaleenmäki H, Farina NH, van Wijnen AJ, Stein JL, Hesse E, Stein GS, Lian JB. Oncotarget. 2016 Nov 29;7(48):79032-79046. doi: 10.18632/oncotarget.12593. PMID: 27738322
  • Cortical-Bone Fragility--Insights from sFRP4 Deficiency in Pyle's Disease. Kiper POS, Saito H, Gori F, Unger S, Hesse E, Yamana K, Kiviranta R, Solban N, Liu J, Brommage R, Boduroglu K, Bonafé L, Campos-Xavier B, Dikoglu E, Eastell R, Gossiel F, Harshman K, Nishimura G, Girisha KM, Stevenson BJ, Takita H, Rivolta C, Superti-Furga A, Baron R. N Engl J Med. 2016 Jun 30;374(26):2553-2562. doi: 10.1056/NEJMoa1509342. PMID:27355534