Results colloquium

David Andreu Sanz, AG Kobold

RoseTTAFold-generated mini binders replacing scFv for CAR T cell therapy

Journal club

Till Johannsmann, AG Daniel

Nakandakari- Higa et al. Universal recording of immune cell interactions in vivo. Nature 2024

Results colloquium

Amelie Muth, AG Subklewe

Modulating Bispecific Antibody-Mediated T Cell Exhaustion by Exposure to Glucocorticoids

Journal club

Rasmus Müller, AG Kobold

Zhao et al. IL-10 expressing CAR T cells resist dysfunction and mediate durable clearance of solid tumors and metastases. Nature Biotechnology 2022

Results colloquium

Dr. Sarah Kim-Hellmuth

The fascinating effects of genetic diversity on the human immune system and beyond

Journal club

Charlotte Carcopino, AG Kobold

Cancelled

Results colloquium

Sabine Oganesian, AG Theurich

Characterization of the Tumormicroenvironment in Cutaneous T cell Lymphoma with a special focus on B cells

Journal club

Mirjam Schobel, AG Rothenfußer/ Kim- Hellmuth

Cancelled

Results colloquium

Lisa Gregor, AG Kobold

Prostanoid- resistant CAR T cells in cancer

Journal club

Sara Egea- Rodriguez, AG Helfrich

Bawden et al. CD4+ T cell immunity against cutaneous melanoma encompasses multifaceted MHC II- dependent responses. Science Immunology 2024

Educational colloquium

Dr. Anne Holtermann, AG Kobold

Cancelled

Journal club

Sandra Dirschl, AG Daniel

Hamilton et al. In vivo human T cell engineering with enveloped delivery vehicles. Nature Biotechnology 2024

Educational colloquium

Dr. Ignazio Piseddu, AG Anz

Cancelled

Journal club

Emre Erdogan, AG Kobold

Corey et al. Novel engineered chimerif engulfment receptors trigger T cell effector functions against SIV-infectes CD4+ T cells. Molecular Therapy 2023

Results colloquium

Julia Teppert, AG König/ Schnurr

Cell death-optimized 5´-triphosphate RNAs for improved tumor immunotherapy

Journal club

Dr. Matthias Thaler, AG Anz

Mackensen et al. "Anti-CD19 CAR T cell therapy for refractory systemic lupus erythematosus". Nature Medicine 2022

Results colloquium

Monika Sponheimer, AG Subklewe

The Yin and Yang of Pro-Inflammatory Cytokines in Antibody-based Immunotherapy of AML: TNF-a Increases the Expression of the Leukemia-Associated Antigen CD70, and IFN-g Dampens ADCC by NK Cells

Journal club

Alexandra Leutbecher, AG Subklewe

Tang et al. CD47 masks pro-phagocytic ligands in cis on tumor cells to suppress antitumor immunity CD47 masks pro-phagocytic ligands in cis on tumor cells to suppress antitumor immunity. Nature Immunology 2023

Results colloquium

Sophie Bernhard, AG Kobold

Arming CAR T cells with C-C-motive receptor 8 for cancer treatment

Journal club

Dr. Matthias Thaler, AG Anz

Cancelled

Results colloquium

Stefan Niedermeier, AG Buchner

Exploring tumor microenvironment remodeling and ferroptosis resistance during Richter transformation

Journal club

Lena Jablonowski, AG Feuchtinger

Xiang et al. An "Off- the- Shelf" CD2 universal CAR- T therapy for T- cell malignancies. Leukemia 2023

Results colloquium

Till Johannsmann, AG Daniel

Novel inducers of Treg cells to control autoimmunity such as T1D

Journal club

Viktoria Hartmann, AG Kobold

Nils Wellhause et al. „Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy“. Science Translational Medicine 2023

Educational colloquium

Dr. Thu Nguyen, AG Kobold

Clinical aspects of CAR- T cell therapy

Journal club

Lena- Maria Jablonowski, AG Feuchtinger

Cancelled

Results colloquium

Alejandro Salinas- Illarena, AG Baldauf

Development of simplified virus- like particles (VLPs) for Vpx delivery to overcome chemotherapy resistance in AML

Journal club

Gordon Hoffmann, AG Kobold

Tousley et al. Co- opting signaling molecules enables logic- gated control of CAR T cells. Nature Cancer 2022

Results colloquium

Mara Henrich, AG Kobold

CAR-T cell therapy in colorectal cancer - Disease specific engineering of CAR-T Cells utilizing chemokine receptors

Journal club

Valerie Kolarik, AG König/ Schnurr

Swietlik et al. Cell-selective proteomics segregates pancreatic cancer subtypes by extracellular proteins in tumors and circulation. Nature Communications 2023

Results colloquium

Viola Siegert, AG Buchner

Metabolic Reprogramming during the transformation of CLL to aggressive lymphom

Journal club

Luana Messa, AG Anz

Tian et al “Specific targeting of glioblastoma with an oncolytic virus expressing a cetuximab- CCL5 fusion protein via innate and adaptive immunity“. Nature Cancer 2022

Results colloquium

Prof. Matthias Kroiß, AG Kroiß

What endocrine tumors can teach about cancer immunology

Journal club

Shenzhi Jia, AG Rothenfußer

Cancelled

Results colloquium

Tanja Maier, AG Kroiß

Towards an understanding of the microenvironment of ACC: Impact of steroid hormones and glucocorticoid receptor signaling

Journal club

Vivien Menkhoff, AG Kobold

Cancelled

Results colloquium

Antonio Santos del Peral, AG Rothenfußer

Basal determinatnts of immune variation and response to the yellow fever vaccine

Journal club

Till Johannsmann, AG Daniel

Zani et al. The dietary sweetener sucaralose is a negative modulator of T cell-mediated responses. Nature 2023

Results colloquium

Prof. Simon Rothenfußer, AG Rothenfußer

Lessons to learn from primary immunodeficiencies

Journal club

Paul Schwarzlmüller, AG Kroiß

Acharya et al. Endogenous Glucocorticoid Signaling Regulates CD8+ T Cell Differentiation and Development of Dysfunction in the Tumor Microenvironment. Immunity 2020

Results colloquium

Sara Egea-Rodriguez, AG Helfrich

High levels of RECQL4 DNA helicase correlate with low numbers of tumor- infiltrating lymphocytes driving poor clinical outcome in patients of mal

Journal club

Lina Majed, AG Kobold

Zhang et al. Reprogramming tumor- associated macrophages to outcompete caner cells. Nature 2023

Results colloquium

Dr. Maike Buchner, AG Ruland, AG Buchner

Signaling thresholds in B cell development an CLL

Journal club

Jingke Tu, AG Theurich

Souza-Fonseca-Guimaraes et al. TGF-β and CIS Inhibition overcomes NK-cell suppression to restore antitumor immunity. Cancer Immunol 2022

Results colloquium

Phillip Müller, AG Kobold

Engineering of novel CAR T cells- Targeting lung cancer specific structures

Journal club

Lina Majed, AG Kobold

How to hold a journal club

(Guideline)

Results colloquium

Alexandra Triebig, AG Kroiß

Targeting the Ferroptosis-Macrophage crosstalk in adrenocortical carcinoma (ACC)

Journal club

Stefan Niedermeier, AG Buchner

Choi et al. Immune checkpoint blockade induces gut microbiota translocation that augments extraintestinal anti-tumor immunity. Science Immunology 2023

Results colloquium

Sandra Dirschl, AG Daniel

T cell specific miRNA targeting in Type 1 Diabetes

Journal club

Mirjam Schobel, AG Rothenfußer und Kim-Hellmuth

Hagan et al. Transcriptional atlas of the human immune response to 13 vaccines reveals a common predictor of vaccine-induced antibody responses. Nat Immunol 2022

Results colloquium

Adriano Carboniero, AG Theurich

Metabolic reprogramming of Natural Killer cells by obesity-associated and tumour-derived cytokine networks

Journal club

Sara Egea-Rodriguez, AG Helfrich

Wang et al., STING agonism reprograms tumor-associated macrophages and overcomes resistance to PARP inhibition in BRCA1-deficient models of breast cancer. Nature Communications 2022

Results colloquium

Amelie Muth, AG Subklewe

Lenalidomide in combination with continuous CD3xCD19 T cell recruiting bispecific antibody treatment maintains T cell function and delays exhaustion

Journal club

Alejandra Hernandez Caceres, AG Hopfner

Yu, X. et al. Reducing affinity as a strategy to boost immunomodulatory antibody agonism. Nature 2023

Results colloquium

Dr. Iman Dalloul, AG Kobold

Canonical Switch in Cis or Trans and IgH Locus Suicide Recombinations

Journal club

Alexandra Leutbecher, AG Subklewe

J. Ding et al. Mesothelin targeting T cells bearing a novel T cell receptor fusion construct TRuC exhibit potent antitumor efficacy against solid tumors. OncoImmunology 2023

Results colloquium Kick-off i-Target 2.0

Emanuele Carlini, AG Kobold

Engineering an atypical cytokine signalling into human CSF-1-responsive CAR T cells