i-Target 2.0 IOLIN seminar program
Location and Time
Results colloquium or educational colloquium: Monday, 17:00 to 18:00
Journal club: Monday, 18:00 to 18:30
Winter semester 2024 / 2025
Upcoming dates
13. January 2025
Guest speaker
Speaker
Prof. Sandrine Dabernat
Topic
n.a.
16. December 2024
Results colloquium
Journal club
Speaker
TBA
Helen Stirling, AG Rothenfußer
Topic
n.a.
n. a.
09. December 2024
Results colloquium
Journal club
Speaker
Alexandra Leutbecher, AG Subklewe
Stefan Niedermeier, AG Buchner
Topic
n.a.
n. a.
02. December 2024
Guest speaker
Speaker
Prof. Lukas Milles
Topic
n.a.
Current date
25. November 2024
Guest speaker
Speaker
PD Dr. Arndt Schottelius
Maxion Therapeutics
Topic
KnotBodies® - Creating ion channel modulating antibodies by fusing Knottins into antibody loops
18. November 2024
Educational colloquium
Journal club
Speaker
Dr. Ngoc-Thien-Thu Nguyen, AG Kobold
Lisa Gregor, AG Kobold
Topic
Immunotherapy in a case
Cancelled
11. November 2024
Results colloquium
Journal club
Speaker
Jan Gärtig, AG Anz
Amelie Muth, AG Subklewe
Topic
CCL22 - the root of all evil?
Guerrero et al. GLUT1 overexpression in CAR-T cells induces metabolic reprogramming and enhances potency, nature communications, 2024
04. November 2024
Results colloquium
Journal club
Speaker
Mara Henrich, AG Kobold
David Andreu Sanz, AG Kobold
Topic
CAR T cell therapy in Colorectal cancer
Feng et al. The type 2 cytokine Fc–IL-4 revitalizes exhausted CD8+ T cells against cancer, Nature, 2024
28. October 2024
Results colloquium
Journal club
Speaker
Rasmus Müller, AG Kobold
Julia Teppert, AG König/ Schnurr
Topic
Serotonin receptor-induced trafficking of CAR T cells into solid tumors
Chibaya et al. Nanoparticle delivery of innate immune agonists combined with senescence-inducing agents promotes T cell control of pancreatic cancer, Science Translational Medicine, 2024
21. October 2024
Results colloquium
Journal club
Speaker
Till Johannsmann, AG Daniel
Alexandra Triebig, AG Kroiß
Topic
Novel modulators of regulatory T cells to control autoimmunity vs cancer
Van Elsas MJ et al. Immunotherapy-activated T cells recruit and late-stage activated M1-like macrophages that are critical for therapeutic efficacy, Cancer Cell, 2024
14. October 2024
Results colloquium
Journal club
Speaker
Stefan Niedermeier, AG Buchner
Sabine Oganesian, AG Theurich
Topic
Tumor microenvironment remodeling and increased ferroptosis sensitivity during Richter Transformation
Gaydosik et al. The mycosis fungoides cutaneous microenvironment shapes dysfunctional cell trafficking, antitumor immunity, matrix interactions, and angiogenesis, JCI Insight, 2023
07. October 2024
Results colloquium
Journal club
Speaker
Emanuele Carlini, AG Kobold
Nilofer Abdul Razak, AG König/ Schnurr
Topic
Introducing a non-canonical IL-23R signalling into CSF-1R+ CAR-T cells
Ng et al. Deterministic reprogramming of neutrophils within tumors, Science, 2024
Summer semester 2024
30. September 2024
Educational colloquium
Speaker
Dr. Marcel Trefny, AG Kobold
Topic
GPCRs for cancer immunotherapy
23. September 2024
Results colloquium
Journal club
Speaker
Monika Sponheimer
Tanja Maier, AG Kroiß
Topic
TNF-alpha and IFN-gamma: The good and evil in CD70-directed NK cell based-Immunotherapy for AML
Wilmouth et al. Sexually dimorphic activation of innate antitumor immunity prevents ACC development, Science Advances, 2022
22. July 2024
Guest speaker
Speaker
Bayer AG
Topic
Targeted radiotherapies: an emerging therapeutic modality driving the promise of precision medicines
15. July 2024
Results colloquium
Journal club
Speaker
Charlotte Carcopino, AG Kobold
Emanuele Carlini, AG Kobold
Topic
Arming iPSC-derived NK cells with a chimeric antigen receptor for the treatment of acute myeloid leukemia
Zhu et al. A novel engineered IL-21 receptor arms T-cell receptor-engineered T cells (TCR-T cells) against hepatocellular carcinoma, Signal Transduct Target Ther 2024
8. July 2024
Results colloquium
Journal club
Speaker
Alejandro Salinas, AG Baldauf
Jan Gärtig, AG Anz
Topic
Optimizing delivery of the lentiviral protein Vpx to overcome chemotherapy resistance in AML
A lactate-SREBP2 signaling axis drives tolerogenic dendritic cell maturation and promotes cancer progression, Science Immunology 2024
1. July 2024
Results colloquium
Journal club
Speaker
Emre Erdogan, AG Kobold
Alexandra Leutbecher, AG Subklewe
Topic
Development of a CAR that specifically and selectively recognizes AML blasts
Sirpα on tumor-associated myeloid cells restrains antitumor immunity in colorectal cancer independent of its interaction with CD47, nature cancer 2024
24. June 2024
Guest speaker
Speaker
Patent Attorney Vossius & Partner
Topic
Patenting of Biotechnology Inventions
17. June 2024
Results colloquium
Journal club
Speaker
Sandra Dirschl, AG Daniel
Adriano Carboniero, AG Teurich
Topic
Restoring impaired Treg cells by targeted miRNA modulation
Macrophage STING signaling promotes NK cell to suppress colorectal cancer liver metastasis via 4-1BBL/4-1BB co-stimulation, Journal for ImmunoTherapy of Cancer 2023
10. June 2024
Guest speaker
Speaker
Roche Diagnostics GmbH
Topic
Bispecific and multifunctional antibodies - From design and selection of the right format and concept to technical development and delivery to clinic
27. May 2024
Results colloquium
Journal club
Speaker
Viola Siegert, AG Buchner
Alejandro Salinas, AG Baldauf
Topic
Metabolic reprogramming during the transformation of CLL to aggressive lymphoma
An oncolytic virus–T cell chimera for cancer immunotherapy, Nature Biotechnology 2024
13. May 2024
Introduction, Team Jobs
Journal club
Speaker
Viola Siegert, AG Buchner
Topic
SLC25A51 decouples the mitochondrial NAD+/NADH ratio to control proliferation of AML cells, Cell metabolism 2024
6. May 2024
Results colloquium
Journal club
Speaker
Tanja Maier, AG Kroiß
Giulia Rappa, AG Subklewe
Topic
Potential immune modulating factor in adrenocortical carcinoma (ACC)
One CD4+TCR and One CD8+TCR Targeting Autochthonous Neoantigens Are Essential and Sufficient for Tumor Eradication, Clin Cancer Research 2024
29. April 2024
Results colloquium
Journal club
Speaker
Alexandra Triebig, AG Kroiß
Linda Hammann, AG Anz
Topic
Targeting macrophages in adrenocortical carcinoma (ACC) – impact of the TME and ferroptosis
Identification of a non-canonical chemokine-receptor pathway suppressing regulatory T cells to drive atherosclerosis”, Nature Cardiovascular Research 2024
22. April 2024
Guest speaker
Speaker
Dr. Laurie Menger
Topic
LET'S IMMUN
Systematic discovery of targets improving T-cell therapy using in vivo genome-wide CRISPR screens
8. April 2024
Results colloquium
Journal club
Speaker
Jingke Tu, AG Theurich
Conghui Wang, AG König / Schnurr
Introduction round, Team jobs
The Characteristics of Obesity-Associated NK Cells deriving from Bone Marrow Hematopoietic Stem/Progenitor Cells
Cancelled
Winter semester 2023 / 2024
18. März 2024
Guest speaker
Speaker
Dr. Andreas Linder
Topic
The Nobel Prize in Medicine 2023 - Breaktrough of mRNA technology
11. März 2024
Results colloquium
Journal club
Speaker
David Andreu Sanz, AG Kobold
Till Johannsmann, AG Daniel
Topic
RoseTTAFold-generated mini binders replacing scFv for CAR T cell therapy
Universal recording of immune cell interactions in vivo, Nature 2024
04. März 2024
Results colloquium
Journal club
Speaker
Amelie Muth, AG Subklewe
Rasmus Müller, AG Kobold
Topic
Modulating Bispecific Antibody-Mediated T Cell Exhaustion by Exposure to Glucocorticoids
IL-10 expressing CAR T cells resist dysfunction and mediate durable clearance of solid tumors and metastases, Nature Biotechnology 2022
26. Februar 2024
Results colloquium
Journal club
Speaker
Dr. Sarah Kim-Hellmuth
Charlotte Carcopino, AG Kobold
Topic
The fascinating effects of genetic diversity on the human immune system and beyond
Cancelled
19. Februar 2024
Results colloquium
Journal club
Speaker
Sabine Oganesian, AG Theurich
Mirjam Schobel,
AG Rothenfußer/ Kim-Hellmuth
Topic
Characterization of the Tumormicorenvironment in Cutaneous T cell Lymphoma with a special focus on B cells
Cancelled
12. Februar 2024
Results colloquium
Journal club
Speaker
Lisa Gregor, AG Kobold
Sara Egea-Rodriguez, AG Helfrich
Topic
Prostanoid-resistant CAR T cells in cancer
CD4+ T cell immunity against cutaneous melanoma encompasses multifaceted MHC II–dependent responses, Science Immunology 2024
05. Februar 2024
Educational colloquium
Journal club
Speaker
Dr. Anne Holtermann, AG Kobold
Sandra Dirschl, AG Kobold
Topic
Cancelled
In vivo human T cell engineering with enveloped delivery vehicles, Nature Biotechnology 2024
22. Januar 2024
Educational colloquium
Journal club
Speaker
Dr. Ignazio Piseddu, AG Anz
Emre Erdogan, AG Kobold
Topic
Cancelled
Novel engineered chimeric engulfment receptors trigger T cell effector functions against SIV-infected CD4+ T cells", Molecular Therapy 2023
15. Januar 2024
Guest speaker
Speaker
Larsen Vornholz
Topic
Tumor-cell intrinsic STING signaling controls antitumor immunity
08. Januar 2024
Results colloquium
Journal club
Speaker
Julia Teppert, AG König/ Schnurr
Dr. Matthias Thaler, AG Anz
Topic
Cell death-optimized 5´-triphosphate RNAs for improved tumor immunotherapy
"Anti-CD19 CAR T cell therapy for refractory systemic lupus erythematosus" Nature Medicine 2022
11. Dezember 2023
Guest speaker
Speaker
Dr. Sarah Kim-Hellmuth
Topic
The fascinating effects of genetic diversity on the human immune system and beyond
04. Dezember 2023
Results colloquium
Journal club
Speaker
Monika Sponheimer, AG Subklewe
Alexandra Leutbecher, AG Subklewe
Topic
The Yin and Yang of Pro-Inflammatory Cytokines in Antibody-based Immunotherapy of AML: TNF-a Increases the Expression of the Leukemia-Associated Antigen CD70, and IFN-g Dampens ADCC by NK Cells
CD47 masks pro-phagocytic ligands in cis on tumor cells to suppress antitumor immunity CD47 masks pro-phagocytic ligands in cis on tumor cells to suppress antitumor immunity, Nature Immunology 2023
27. November 2023
Results colloquium
Journal club
Speaker
Sophie Bernhard, AG Kobold
Dr. Matthias Thaler, AG Anz
Topic
Arming CAR T cells with C-C-motive receptor 8 for cancer treatment
Cancelled
20. November 2023
Results colloquium
Journal club
Speaker
Stefan Niedermeier, AG Buchner
Lena Jablonowski, AG Feuchtinger
Topic
Exploring tumor microenvironment remodeling and ferroptosis resistance during Richter transformation
An „Off-the-Shelf“ CD2 universal CAR-T therapy for T-cell malignancies, Leukemia 2023
13. November 2023
Results colloquium
Journal club
Speaker
Till Johannsmann, AG Daniel
Viktoria Hartmann, AG Kobold
Topic
Novel inducers of Treg cells to control autoimmunity such as T1D
Nils Wellhause et al. „Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy“
6. November 2023
Educational colloquium
Journal club
Speaker
Dr. Thu Nguyen, AG Kobold
Lena-Maria Jablonowski, AG Feuchtinger
Topic
Clinical aspects of CAR-T Cell therapy
Cancelled
30. Oktober 2023
Results colloquium
Journal club
Speaker
Alejandro Salinas-Illarena, AG Baldauf
Gordon Hoffmann, AG Kobold
Topic
Development of simplified virus-like particles (VLPs) for Vpx delivery to overcome chemotherapy resistance in AML
Co-opting signalling molecules enables logic- gated control of CAR T cells, Nature Cancer 2022
16. Oktober 2023
Results colloquium
Journal club
Speaker
Mara Henrich, AG Kobold
Valerie Kolarik, AG König/ Schnurr
Topic
CAR-T cell therapy in colorectal cancer - Disease specific engineering of CAR-T Cells utilizing chemokine receptors
Swietlik et al: “Cell-selective proteomics segregates pancreatic cancer subtypes by extracellular proteins in tumors and circulation“, Nature Communications 2023
9. Oktober 2023
Guest speaker
Speaker
Prof. Dr. Ralf Jungmann
Topic
Localizomics: towards spatial omics using DNA-based super-resolution microscopy
2. Oktober 2023
Results colloquium
Journal club
Speaker
Viola Siegert, AG Buchner
Luana Messa, AG Anz
Topic
Metabolic Reprogramming during the transformation of CLL to aggressive lymphom
Tian et al “Specific targeting of glioblastoma with an oncolytic virus expressing a cetuximab- CCL5 fusion protein via innate and adaptive immunity“, Nature Cancer 2022
25. September 2023
Educational colloquium
Journal club
Speaker
Prof. Matthias Kroiß, AG Kroiß
Shenzhi Jia, AG Rothenfußer
Topic
What endocrine tumours can teach about cancer immunology
//
18. September 2023
Results colloquium
Journal club
Speaker
Tanja Maier, AG Kroiß
Vivien Menkhoff, AG Kobold
Topic
Towards an understanding of the microenvironment of ACC: Impact of steroid hormones and glucocorticoid receptor signaling
//
Summer semester 2023
24. Juli 2023
Results colloquium
Journal club
Speaker
Antonio Santos del Peral, AG Rothenfußer
Till Johannsmann, AG Daniel
Topic
Basal determinatnts of immune variation and response to the yellow fever vaccine
The dietary sweetener sucaralose is a negative modulator of T cell-mediated responses, Nature 2023
17. Juli 2023
Educational colloquium
Journal club
Speaker
Prof. Simon Rothenfußer, AG Rothenfußer
Paul Schwarzlmüller, AG Kroiß
Topic
Lessons to learn from primary immunodeficiencies
Endogenous Glucocorticoid Signaling Regulates CD8+ T Cell Differentiation and Development of Dysfunction in the Tumor Microenvironment
10. Juli 2023
Results colloquium
Journal club
Speaker
Sara Egea-Rodriguez, AG Helfrich
Lina Majed, AG Kobold
Topic
High levels of RECQL4 DNA helicase correlate with low numbers of tumorinfiltrating lymphocytes driving poor clinical outcome in patients of mal
Reprogramming tumour-associated macrophages to outcompete cancer cells, Nature 2023
3. Juli 2023
Educational colloquium
Journal club
Speaker
Dr. Maike Buchner, AG Ruland, AG Buchner
Jingke Tu, AG Theurich
Topic
Signaling thresholds in B cell development an CLL
TGF-β and CIS Inhibition overcomes NK-cell suppression to restore antitumor immunity, Cancer Immunol 2022
26. Juni 2023
Results colloquium
Journal club
Speaker
Phillip Müller, AG Kobold
Lina Majed, AG Kobold
Topic
Engineering of novel CAR T cells - Targeting lung cancer specific structures
How to hold a journal club
(Guideline)
19. Juni 2023
Results colloquium
Journal club
Speaker
Alexandra Triebig, AG Kroiß
Stefan Niedermeier, AG Buchner
Topic
Targeting the Ferroptosis-Macrophage crosstalk in adrenocortical carcinoma (ACC)
Choi et al. Immune checkpoint blockade induces gut microbiota translocation that augments extraintestinal anti-tumor immunity, Science Immunology 2023
12 Juni 2023
Guest speaker
Speaker
Prof. Dr. Per Thor Straten
Topic
The exercise of TAMing the immune system
5. Juni 2023
Results colloquium
Journal club
Speaker
Sandra Dirschl, AG Daniel
Mirjam Schobel, AG Rothenfußer und Kim-Hellmuth
Topic
T cell specific miRNA targeting in Type 1 Diabetes
Hagan et al. Transcriptional atlas of the human immune response to 13 vaccines reveals a common predictor of vaccine-induced antibody responses. Nat Immunol 2022
29. Mai 2023
Public Holiday:
Pfingsten
22. Mai 2023
Results colloquium
Journal club
Speaker
Adriano Carboniero, AG Theurich
Sara Egea-Rodriguez, AG Helfrich
Topic
Metabolic reprogramming of Natural Killer cells by obesity-associated and tumour-derived cytokine networks
Wang et al., STING agonism reprograms tumor-associated macrophages and overcomes resistance to PARP inhibition in BRCA1-deficient models of breast cancer, Nature Communications 2022
15. Mai 2023
Results colloquium
Journal club
Speaker
Amelie Muth, AG Subklewe
Alejandra Hernandez Caceres, AG Hopfner
Topic
Lenalidomide in combination with continuous CD3xCD19 T cell recruiting bispecific antibody treatment maintains T cell function and delays exhaustion
Yu, X. et al. Reducing affinity as a strategy to boost immunomodulatory antibody agonism. Nature 2023
8. Mai 2023
Educational colloquium
Journal club
Speaker
Dr. Iman Dalloul, AG Kobold
Alexandra Leutbecher, AG Subklewe
Topic
Canonical Switch in Cis or Trans and IgH Locus Suicide Recombinations
J. Ding et al. Mesothelin targeting T cells bearing a novel T cell receptor fusion construct TRuC exhibit potent antitumor efficacy against solid tumors, OncoImmunology 2023
24. April 2023
Results colloquium introduction round and distribution of team jobs
Speaker
Julia Teppert, AG König and Marx
Topic
Cell death-optimized 5’-triphosphate RNAs for improved tumor immunotherapy
17. April 2023
Results colloquium Kick-off i-Target 2.0
Speaker
Emanuele Carlini, AG Kobold
Topic
Engineering an atypical cytokine signalling into human CSF-1-responsive CAR T cells
