Results colloquium

David Andreu Sanz, AG Kobold

RoseTTAFold binders as a powerful tool to leverage CAR T cell therapy

Journal club

Philipp Menauer, AG Kobold

Prasad et al. Antibiotic-induced loss of gut microbiome metabolic output correlates with clinical responses to CAR T-cell therapy, Blood 2025

Results colloquium

Viola Siegert, AG Buchner

Metabolic reprogramming in Richter Transformation

Journal club

Anja Hauptstein, AG Kobold

Silvia et al. CD70 CAR T cells secreting an anti-CD33/anti-CD3 dual-targeting antibody overcome antigen heterogeneity in AML, Blood 2025

Results colloquium

Sabine Oganesian, AG Theurich

Multidimensional charazteriation of the microenvironment in CTCL with a special focus on B cells

Journal club

Ziting Zhang, AG Helfrich

Stejerean-Todoran et al. A distinct pattern of growth and RAC1 signaling in melanoma brain metastasis cells, Neuro Oncol 2023

Results colloquium

Giulia Rappa, AG Subklewe

In vitro stimulation of T cells to fight AML

Journal club

Andrew Sursanto, AG König Schnurr

Park et al. Hematopoietic aging promotes cancer by fueling IL-1⍺–driven emergency myelopoiesis, Science 2024

Guest speaker

Dr. med. Sonja Wörmann

Group Leader, TUM University Hospital 

APOBEC3A - Driver of chromosomal instability and metastasis in pancreatic cancer

Results colloquium

Sara Egea- Rodriguez, AG Helfrich

RECQL4-mediated downregulation of MHC class II promotes immune evasion and reduced anti-PD-1 response in melanoma patients

Journal club

Selin Aidin, AG Baldauf

Wen et al. Epstein-Barr virus infection upregulates extracellular OLFM4 to activate YAP signaling during gastric cancer progression. Nature Communications 2024

Results colloquium

Lisa Gregor, AG Kobold

Ablation of prostaglandin E2 signaling through receptor knockouts enables CAR T cell therapy of solid tumors

Journal club

Vanessa Wittmann, AG Anz

Damasceno et al. STING is an intrinsic checkpoint inhibitor that restrains the TH17 cell pathogenic program. Cell Reports 2022

Guest speaker

Prof. Dr. Dominik Wolf

Head of the Department of Internal Medicine V (Hematology and Oncology), Medical University of Innsbruck

Myeloid inflammation in health and cancer

Results colloquium

Linda Hammann, AG Anz

The impact of CCR4 ligands on tissue Treg cells in islet autoimmunity

Journal club

Daria Shvets, AG Kobold

Hänggi K et al. 2024 Interleukin-1a release during necrotic-like cell death generates myeloid-driven immunosuppression that restricts anti-tumor immunity. Cancer Cell 2024

Results colloquium

Julia Teppert, AG König Schnurr

Cell death-optimized 3p-RNAs for improved tumor immunotherapy

Journal club

Rasmus Müller, AG Kobold

Qiu et al. Mannose metabolism reshapes T cell differentiation to enhance anti-tumor immunity. Cancer Cell 2024

Educational colloquium

Dr. med. vet. Charlotte Marx

High- Dimensional flow cytometry in cancer research 

Journal club

Helen Stirling, AG Rothenfußer

Singh et al. A Zika virus- specific lgM elicites in pregnany exhibits ultrapotent neutralization. Cell 2022

Results colloquium

Alexandra Leutbecher, AG Subklewe

Antibody-based immunotherapy for the treatment of epithelial ovarian cancer

Journal club

Distribution of team jobs for 2025

Stefan Niedermeier, AG Buchner

Baldwin et al. Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy. Cell 2024

Results colloquium

Dr. Ngoc-Thien-Thu Nguyen, AG Kobold

Immunotherapy in a case

Journal club

Lisa Gregor, AG Kobold

Cancelled

Results colloquium

Jan Gärtig, AG Anz

CCL22 - the root of all evil?

Journal club

Amelie Muth, AG Subklewe

Guerrero et al. GLUT1 overexpression in CAR-T cells induces metabolic reprogramming and enhances potency. Nature Communications 2024

Results colloquium

Rasmus Müller, AG Kobold

Serotonin receptor-induced trafficking of CAR T cells into solid tumors

Journal club

Julia Teppert, AG König/ Schnurr

Chibaya et al. Nanoparticle delivery of innate immune agonists combined with senescence-inducing agents promotes T cell control of pancreatic cancer. Science Translational Medicine 2024

Results colloquium

Till Johannsmann, AG Daniel

Novel modulators of regulatory T cells to control autoimmunity vs cancer

Journal club

Alexandra Triebig, AG Kroiß

Van Elsas MJ et al. Immunotherapy-activated T cells recruit and late-stage activated M1-like macrophages that are critical for therapeutic efficacy. Cancer Cell 2024

Results colloquium

Stefan Niedermeier, AG Buchner

Tumor microenvironment remodeling and increased ferroptosis sensitivity during Richter Transformation

Journal club

Sabine Oganesian, AG Theurich

Gaydosik et al. The mycosis fungoides cutaneous microenvironment shapes dysfunctional cell trafficking, antitumor immunity, matrix interactions, and angiogenesis. JCI Insight 2023

Results colloquium

Emanuele Carlini, AG Kobold

Introducing a non-canonical IL-23R signalling into CSF-1R+ CAR-T cells

Journal club

Nilofer Abdul Razak, AG König/ Schnurr

Ng et al. Deterministic reprogramming of neutrophils within tumors. Science 2024

Results colloquium

Monika Sponheimer

TNF-alpha and IFN-gamma: The good and evil in CD70-directed NK cell based-Immunotherapy for AML

Journal club

Tanja Maier, AG Kroiß

Wilmouth et al. Sexually dimorphic activation of innate antitumor immunity prevents ACC development. Science Advances 2022

Results colloquium

Charlotte Carcopino, AG Kobold

Arming iPSC-derived NK cells with a chimeric antigen receptor for the treatment of acute myeloid leukemia

Journal club

Emanuele Carlini, AG Kobold

Zhu et al. A novel engineered IL-21 receptor arms T-cell receptor-engineered T cells (TCR-T cells) against hepatocellular carcinoma. Signal Transduct Target Therapy 2024

Results colloquium

Alejandro Salinas, AG Baldauf

Optimizing delivery of the lentiviral protein Vpx to overcome chemotherapy resistance in AML

Journal club

Jan Gärtig, AG Anz

Plebanek et al. A lactate-SREBP2 signaling axis drives tolerogenic dendritic cell maturation and promotes cancer progression. Science Immunology 2024

Results colloquium

Emre Erdogan, AG Kobold

Development of a CAR that specifically and selectively recognizes AML blasts

Journal club

Alexandra Leutbecher, AG Subklewe

Huang et al. Sirpα on tumor-associated myeloid cells restrains antitumor immunity in colorectal cancer independent of its interaction with CD47. Nature Cancer 2024

Results colloquium

Sandra Dirschl, AG Daniel

Restoring impaired Treg cells by targeted miRNA modulation

Journal club

Adriano Carboniero, AG Teurich

Sun et al. Macrophage STING signaling promotes NK cell to suppress colorectal cancer liver metastasis via 4-1BBL/4-1BB co-stimulation. Journal for ImmunoTherapy of Cancer 2023

Results colloquium

Viola Siegert, AG Buchner

Metabolic reprogramming during the transformation of CLL to aggressive lymphoma

Journal club

Alejandro Salinas, AG Baldauf

Chen et al. An oncolytic virus–T cell chimera for cancer immunotherapy, Nature Biotechnology 2024

Introduction, Team Jobs

Journal club

Viola Siegert, AG Buchner

Lu et al. SLC25A51 decouples the mitochondrial NAD+/NADH ratio to control proliferation of AML cells. Cell metabolism 2024

Results colloquium

Tanja Maier, AG Kroiß

Potential immune modulating factor in adrenocortical carcinoma (ACC)

Journal club

Giulia Rappa, AG Subklewe

Wolf et al. One CD4+TCR and One CD8+TCR Targeting Autochthonous Neoantigens Are Essential and Sufficient for Tumor Eradication. Clinical Cancer Research 2024

Results colloquium

Alexandra Triebig, AG Kroiß

Targeting macrophages in adrenocortical carcinoma (ACC) – impact of the TME and ferroptosis

Journal club

Linda Hammann, AG Anz

Döring et al. Identification of a non-canonical chemokine-receptor pathway suppressing regulatory T cells to drive atherosclerosis”. Nature Cardiovascular Research 2024

Results colloquium

Jingke Tu, AG Theurich

The Characteristics of Obesity-Associated NK Cells deriving from Bone Marrow Hematopoietic Stem/Progenitor Cells