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Medizinische Klinik und Poliklinik IV
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  2. Med IV
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  4. Endokrinologie, Diab. &  Stoffwechsel
  5. Congenital adrenal hyperplasia (AG Reisch)
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                                                  • Endokrinologie, Diab. &  Stoffwechsel
                                                    • Clinical Decision Making (AG Schmidmaier)
                                                       
                                                      • Congenital adrenal hyperplasia (AG Reisch)
                                                         
                                                        • Diabetology (AG Seißler)
                                                           
                                                        • Endocrine Diagnostics (AG Bidlingmaier)
                                                          • Publikationen 2019 
                                                             
                                                            • Publikationen 2020
                                                               
                                                              • Verpflichtende Erklärung gemäß IVDR
                                                                 
                                                                • Publikationen 2021
                                                                   
                                                                  • Publikationen 2019
                                                                     
                                                                    • Publikationen 2018
                                                                       
                                                                      • Publikationen 2023
                                                                         
                                                                        • Publikationen 2017 
                                                                           
                                                                          • Publikationen 2021 
                                                                             
                                                                            • Publikationen 2022
                                                                               
                                                                            • Endocrine Oncology (AG Kroiss)
                                                                               
                                                                            • Epigenetics of Adrenal Cushing's Syndrome (AG Riester/Vetrivel)
                                                                               
                                                                              • ERC PAPA
                                                                                • Cell Biology PAPA
                                                                                   
                                                                                  • Mass Spectrometry PAPA
                                                                                     
                                                                                    • Perspectives PAPA
                                                                                       
                                                                                    • Metabolism (AG Parhofer)
                                                                                       
                                                                                      • Neuroendocrine Tumors (AG Nölting/Auernhammer)
                                                                                         
                                                                                      • Neuroendocrinology (AG Theodoropoulou)
                                                                                         
                                                                                        • Pathophysiology of Primary Aldosteronism (AG Williams)
                                                                                           
                                                                                          • Translational Thyroid Oncology (AG Spitzweg)
                                                                                             
                                                                                        • Infektiologie
                                                                                           
                                                                                          • Internistische Psychosomatik
                                                                                             
                                                                                            • Nephrology
                                                                                              • Active Clinical Trials
                                                                                                 
                                                                                                • Clinical Trials
                                                                                                   
                                                                                                  • AG Fischereder
                                                                                                     
                                                                                                    • AG Vielhauer
                                                                                                       
                                                                                                      • AG Lech
                                                                                                         
                                                                                                        • AG Lichtnekert
                                                                                                           
                                                                                                          • AG Steiger
                                                                                                             
                                                                                                            • AG Anders
                                                                                                               
                                                                                                              • Professor Helen Liapis
                                                                                                                 
                                                                                                                • AG Schönermarck
                                                                                                                   
                                                                                                                • Geriatrics
                                                                                                                  • Doctoral theses
                                                                                                                     
                                                                                                                    • Selected awards and honors
                                                                                                                       
                                                                                                                    • Notfallmedizin
                                                                                                                       
                                                                                                                    • Aus-, Fort- und Weiterbildung
                                                                                                                      • Praktisches Jahr
                                                                                                                        • Wir lernen Medizin
                                                                                                                           
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                                                                                                                                            Congenital adrenal hyperplasia (AG Reisch)

                                                                                                                                            Research

                                                                                                                                            The focus of Prof. Reisch’s research is on congenital gonadal and adrenal disorders. In particular, Prof. Reisch is a leading international expert in congenital adrenal hyperplasia (CAH). CAH is one of the most common diseases in the group of rare diseases with an incidence of 1:10,000 to 1:15,000. Since the introduction of glucocorticoid replacement therapy sixty years ago, CAH has been regarded as a prototype for a treatable genetic disease and, later, for genetic screening in human populations. It is a disease that is relevant for endocrinologists, geneticists, gynaecologists, urologists, (paediatric) surgeons as well as psychologists. For many years CAH was considered a paediatric disease. Only quite recently has the focus shifted also to adult patients and clinicians have begun to realise the substantial morbidity and increased mortality in patients with CAH.



                                                                                                                                            Main research topics

                                                                                                                                            • Molecular mechanisms of CAH
                                                                                                                                            Protein misfolding and protein-protein interactions as molecular pathophysiological background in congenital adrenal hyperplasia (CAH) potentially offering novel therapeutic options with pharmacological chaperons
                                                                                                                                            • Natural history and outcome of CAH
                                                                                                                                            From research of health care provision to evidence based medicine: Natural history, outcome and comorbidities in CAH as examples for effects and side effects of glucocorticoids and sex steroids
                                                                                                                                            • Novel medical treatment of CAH
                                                                                                                                            • Novel diagnostic procedures of CAH


                                                                                                                                            Clinical Studies:

                                                                                                                                            Chronocort:

                                                                                                                                            • International Phase III study
                                                                                                                                            • Study of efficacy, safety and tolerability of Chronocort® compared with standard glucocorticoid replacement therapy in the treatment of congenital adrenal hyperplasia
                                                                                                                                            • The first orphan drug for CAH
                                                                                                                                            • Sponsor: Diurnal Ltd

                                                                                                                                            Tildacerfont 203:
                                                                                                                                            International Phase II b study

                                                                                                                                            Dose-Ranging Study to Evaluate the Efficacy and Safety of SPR001 (Tildacerfont) in Adult Subjects with CAH

                                                                                                                                            Tildacerfont: a potent and highly selective small-molecule antagonist of CRF type 1 (CRF1) receptors in the pituitary gland, is being studied for the treatment of CAH on the basis of its ability to block the CRF signal produced by the hypothalamus, thereby decreasing ACTH overproduction by the pituitary and reducing excess accumulation of downstream adrenal hormones

                                                                                                                                            Sponsor: Spruce Biosciences, Inc.

                                                                                                                                             

                                                                                                                                            Tildacerfont 204:

                                                                                                                                            • International Phase II b study
                                                                                                                                            • Study to Evaluate the Efficacy and Safety of SPR001 (Tildacerfont) in Reducing Supraphysiologic Glucocorticoid Use in Adult Subjects with CAH
                                                                                                                                            • Tildacerfont: a potent and highly selective small-molecule antagonist of CRF type 1 (CRF1) receptors in the pituitary gland, is being studied for the treatment of CAH on the basis of its ability to block the CRF signal produced by the hypothalamus, thereby decreasing ACTH overproduction by the pituitary and reducing excess accumulation of downstream adrenal hormones.
                                                                                                                                            • Sponsor: Spruce Biosciences, Inc.


                                                                                                                                            Crinecerfont:

                                                                                                                                            • International Phase III study
                                                                                                                                            • Study to Evaluate the Safety and Efficacy of Crinecerfont (NBI-74788) in Adult Subjects with Classic Congenital Adrenal Hyperplasia
                                                                                                                                            • Crinecerfont: A selective corticotropin-releasing hormone receptor 1(CRF1) antagonist that is being developed as a novel oral treatment of congenital adrenal hyperplasia associated with high adrenocorticotropin and adrenal steroid insufficiency.
                                                                                                                                            • Sponsor: Neurocrine Biosciences, Inc.


                                                                                                                                            PREDICT

                                                                                                                                            • International Phase II dose finding study
                                                                                                                                            • Confirmatory clinical trial
                                                                                                                                            • Study to determine the efficacy and safety of a pharmacokinetic-based low dose of prenatal dexamethasone in preventing female prenatal virilisation in CAH.

                                                                                                                                            Mitarbeiter

                                                                                                                                            PI/ Leitung: Prof. Dr. Nicole Reisch

                                                                                                                                            Medizinische Klinik und Poliklinik IV
                                                                                                                                            Ziemssenstraße 1 80336 München
                                                                                                                                            089 4400 52390
                                                                                                                                            Riopibgplgb-Bilcyzvim ful+vfiuyYziu-mi

                                                                                                                                            Biography:

                                                                                                                                            Nicole Reisch qualified in Medicine at the University of Rostock and Albert-Ludwigs- Universität Freiburg i.Breisgau, Germany, in 2002. Four years later she obtained an academic MD degree with distinction. After her core medical training she trained in Endocrinology from 2003-2008 at the University Hospital Freiburg, Germany and the University Hospital of Munich (LMU). Supported by a Postdoctoral Research Fellowship for career development she then spent two years in the Centre for Endocrinology of the College of Medical and Dental Sciences at the University of Birmingham, UK. Following her return to Munich in 2010 she worked as Clinical scientist before she became assistant Professor at the Dept of Endocrinology at University Hospital of Munich (LMU) in 2014.

                                                                                                                                            2017 she obtained the Heisenberg-Professorship and was appointed Professor for Endocrinology.


                                                                                                                                            Qualifications:

                                                                                                                                            since 2017            Heisenberg-Professorship (W2), Endocrinology, Medizinische Klinik IV, Munich, Germany

                                                                                                                                            2014-2017            Assistant Professor at Dept of Endocrinology, Medizinische Klinik und Poliklinik IV, Munich

                                                                                                                                            2015                      Habilitation, Venia legendi Internal Medicine

                                                                                                                                            2014                      Board certificate Internal Medicine, Endocrinology, Diabetology

                                                                                                                                            2008                      British Medical License: GMC-UK

                                                                                                                                            2006                      MD (Dr. med.) with distinction (summa cum laude)

                                                                                                                                            1996-2002            Studies of Medicine (1996-2002)


                                                                                                                                            Research

                                                                                                                                            The focus of Prof. Reisch’s research is on congenital gonadal and adrenal disorders. In particular, Prof. Reisch is a leading international expert in congenital adrenal hyperplasia (CAH). CAH is one of the most common diseases in the group of rare diseases with an incidence of 1:10,000 to 1:15,000. Since the introduction of glucocorticoid replacement therapy sixty years ago, CAH has been regarded as a prototype for a treatable genetic disease and, later, for genetic screening in human populations. It is a disease that is relevant for endocrinologists, geneticists, gynaecologists, urologists, (paediatric) surgeons as well as psychologists. For many years CAH was considered a paediatric disease. Only quite recently has the focus shifted also to adult patients and clinicians have begun to realise the substantial morbidity and increased mortality in patients with CAH.


                                                                                                                                            Other activities:

                                                                                                                                            Since 2020          vice president of the German Society of Endocrinology (DGE)

                                                                                                                                            Since 2017          national Coordinator Endo ERN (European Reference Network in Rare Endocrine Conditions)

                                                                                                                                            Since 2017          endo ERN Chair Main Thematic Group Adrenal

                                                                                                                                            Since 2017          member of the Project Governing Board of EuRRECa (European Registries for Rare Endocrine Conditions)

                                                                                                                                            Since 2008          medical advisor to the German Congenital Adrenal Hyperplasia patient support group (AGS-Eltern- und Patienteninitiative e.V.)


                                                                                                                                            • Publications

                                                                                                                                            Wissenschaftliche Mitarbeiter:

                                                                                                                                            Dr. Matthias Auer

                                                                                                                                            https://pubmed.ncbi.nlm.nih.gov/?term=Matthias+Auer

                                                                                                                                            Dr. Christian Lottspeich

                                                                                                                                            https://pubmed.ncbi.nlm.nih.gov/?term=Christian+Lottspeich

                                                                                                                                            Hanna Franziska Nowotny

                                                                                                                                            https://pubmed.ncbi.nlm.nih.gov/33661460/

                                                                                                                                            Lea Tschaidse

                                                                                                                                            Wei Zhang

                                                                                                                                            https://pubmed.ncbi.nlm.nih.gov/30352420/

                                                                                                                                            Study Nurses:

                                                                                                                                            Magdalena Maurer

                                                                                                                                            Ann-Christin Welp

                                                                                                                                            Labor Mitarbeiter:

                                                                                                                                            Bouamar Eddaoudi

                                                                                                                                            Fatemeh Promoli

                                                                                                                                            Kontakt

                                                                                                                                            Medizinische Klinik und Poliklinik IV

                                                                                                                                            Ziemssenstraße 1
                                                                                                                                            80336 München
                                                                                                                                            089 4400 52390
                                                                                                                                            Riopibgplgb;-Bilcyzvim fulGvfiuSyziusmi

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                                                                                                                                            mehr Informationen

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                                                                                                                                            Campus Großhadern: Marchioninistraße 15, 81377 München

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                                                                                                                                            Medizinische...

                                                                                                                                            • Patientenportal
                                                                                                                                              • Endokrinologie, Diab. & Stoffwechsel
                                                                                                                                                • Endokrinologie
                                                                                                                                                  • Hypophyse 
                                                                                                                                                • Diabetologie
                                                                                                                                                • Stoffwechsel
                                                                                                                                              • Angiologie 
                                                                                                                                              • Geriatrie
                                                                                                                                                • Unterstützen Sie die Geriatrie
                                                                                                                                                • Kontakt zur Geriatrie
                                                                                                                                              • Infektiologie
                                                                                                                                              • Intensivmedizin
                                                                                                                                              • internistische Psychosomatik
                                                                                                                                              • Nephrologie
                                                                                                                                              • Notfallmedizin
                                                                                                                                              • Rheumatologisches Zentrum
                                                                                                                                                • Krankheitsbilder
                                                                                                                                                • Terminvergabe
                                                                                                                                              • Sonographie
                                                                                                                                            • Fach- und Arztinformationen
                                                                                                                                              • Endokrinologie
                                                                                                                                              • Diabetologie
                                                                                                                                              • Stoffwechsel
                                                                                                                                              • Angiologie 
                                                                                                                                              • Geriatrie
                                                                                                                                                • Unterstützen Sie die Geriatrie
                                                                                                                                              • Infektiologie
                                                                                                                                              • Intensivmedizin
                                                                                                                                              • Internistische Psychosomatik
                                                                                                                                              • Nephrologie
                                                                                                                                                • Klinische Studien
                                                                                                                                              • Notfallmedizin
                                                                                                                                              • Rheumatologie
                                                                                                                                            • Ärztinnen und Ärzte
                                                                                                                                            • Research
                                                                                                                                              • Angiology
                                                                                                                                              • Endokrinologie, Diab. &  Stoffwechsel
                                                                                                                                                • Clinical Decision Making (AG Schmidmaier)
                                                                                                                                                • Congenital adrenal hyperplasia (AG Reisch)
                                                                                                                                                • Diabetology (AG Seißler)
                                                                                                                                                • Endocrine Diagnostics (AG Bidlingmaier)
                                                                                                                                                  • Publikationen 2019 
                                                                                                                                                  • Publikationen 2020
                                                                                                                                                  • Verpflichtende Erklärung gemäß IVDR
                                                                                                                                                  • Publikationen 2021
                                                                                                                                                  • Publikationen 2019
                                                                                                                                                  • Publikationen 2018
                                                                                                                                                  • Publikationen 2023
                                                                                                                                                  • Publikationen 2017 
                                                                                                                                                  • Publikationen 2021 
                                                                                                                                                  • Publikationen 2022
                                                                                                                                                • Endocrine Oncology (AG Kroiss)
                                                                                                                                                • Epigenetics of Adrenal Cushing's Syndrome (AG Riester/Vetrivel)
                                                                                                                                                • ERC PAPA
                                                                                                                                                  • Cell Biology PAPA
                                                                                                                                                  • Mass Spectrometry PAPA
                                                                                                                                                  • Perspectives PAPA
                                                                                                                                                • Metabolism (AG Parhofer)
                                                                                                                                                • Neuroendocrine Tumors (AG Nölting/Auernhammer)
                                                                                                                                                • Neuroendocrinology (AG Theodoropoulou)
                                                                                                                                                • Pathophysiology of Primary Aldosteronism (AG Williams)
                                                                                                                                                • Translational Thyroid Oncology (AG Spitzweg)
                                                                                                                                              • Infektiologie
                                                                                                                                              • Internistische Psychosomatik
                                                                                                                                              • Nephrology
                                                                                                                                                • Active Clinical Trials
                                                                                                                                                • Clinical Trials
                                                                                                                                                • AG Fischereder
                                                                                                                                                • AG Vielhauer
                                                                                                                                                • AG Lech
                                                                                                                                                • AG Lichtnekert
                                                                                                                                                • AG Steiger
                                                                                                                                                • AG Anders
                                                                                                                                                • Professor Helen Liapis
                                                                                                                                                • AG Schönermarck
                                                                                                                                              • Geriatrics
                                                                                                                                                • Doctoral theses
                                                                                                                                                • Selected awards and honors
                                                                                                                                              • Notfallmedizin
                                                                                                                                            • Aus-, Fort- und Weiterbildung
                                                                                                                                              • Praktisches Jahr
                                                                                                                                                • Wir lernen Medizin
                                                                                                                                                • Rotationen- Wir machen Medizin
                                                                                                                                                • Betreuung
                                                                                                                                                • Ausstattung
                                                                                                                                              • Stellenangebote und Bewerbung
                                                                                                                                              • IMPROCUSH-5
                                                                                                                                                • Home
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                                                                                                                                                • Registration
                                                                                                                                                • Contact
                                                                                                                                              • Veranstaltungen
                                                                                                                                              • Weiterbildungsermächtigungen 
                                                                                                                                            • Telefon, Kontakt, Anfahrt
                                                                                                                                              • Ambulante Wiedervorstellung